I love visiting San Francisco on work-trips, but it's really getting killed by wealth inequality. I read one article that showed significant observable impact on housing prices in San Francisco every time one of the "app companies" (Twitter, Square, Air B&B, etc) went public. A lot of these companies that are based on a single phone app are based right in San Francisco instead of Silicon Valley. I mean, there was crazy inequality before the app economy, but now it's an order of magnitude worse. Now it's like everyone is either wealthy or living on the fringe. Last time I was there for a work trip to the Apple World Wide Developer's Conference, which was quite a while ago now, I was in a $600/night hotel room. If I walked for a block or two in one direction from my hotel I could shop at a Tiffany's. If I walked a block the other direction, I could be in a sketchy liquor store on the border of the Tenderloin. I walked over to buy a six pack to stock up my hotel fridge, and a dude decided to whip his dick out and **** on the sidewalk right in front of me on broad daylight. I met some interesting characters hanging out at the bar at the Gold Dust Lounge on Powell St, during various work trips, but sadly I believe that bar is no more.