Single table, no playoffs works in Europe for several reasons: most teams have something to play for. Europe, promotion, relegation, etc.
Take the argument that you need to give more teams something to play for at the end of the season. Use the 2007 NFL season as an example. The Patriots were 16-0... I forgot how all the 13-3 teams finished, but effectively the last week or two the season would not have mattered one bit. With nothing else to play for (no relegation, no continental tourneys, no playoffs, etc.), NONE of those games would have meant anything. Several teams would've had meaningless seasons from like week 3 onward, even if they didn't know that New England would post a 16-0 record.
Obviously, teams would have local pride on the line, week in, week out, but that's about it.