Covid 19

[HockeyRef]

Re: Covid 19

Senator Rand Paul tests positive (but is asymptomatic) for the coronavirus. Voting against the relief bill is not a good look. But, sending him thoughts and prayers.

Ps...must be nice people of privilege, NBA players, US Senators, etc can just get a test when unless you're dying of it, you can't. Ho hum...

 

[Darius]

Re: Covid 19

Senator Rand Paul tests positive (but is asymptomatic) for the coronavirus. Voting against the relief bill is not a good look. But, sending him thoughts and prayers.

Ps...must be nice people of privilege, NBA players, US Senators, etc can just get a test when unless you're dying of it, you can't. Ho hum...

Love him or hate him, one has to respect that he has beliefs and stands by them.

 

[Chuck Murray]

Re: Covid 19

Senator Rand Paul tests positive (but is asymptomatic) for the coronavirus. Voting against the relief bill is not a good look. But, sending him thoughts and prayers.

Ps...must be nice people of privilege, NBA players, US Senators, etc can just get a test when unless you're dying of it, you can't. Ho hum...

Money still talks, and the NBA is still in bed with the Chinese Communists, as evidenced by the blowback after Morey's comments in September '19. So maybe access to some extra test kits this was a perk to them, in exchange for toeing the line with Beijing?

I know, it sounds crazy … but as you say in the other instance HR, it's not a good look.

I also think the situations with Sen. Burr (R-NC) and Sen. Feinstein (D-CA) on insider trading is appalling. Sen. Loeffler (R-GA) and Sen. Inhofe (R-OK) are also facing questions. Burr and Feinstein seem to have direct day-to-day control over handling of their portfolio (although Feinstein so far seems content with throwing her husband under the bus), while Loeffler and Inhofe claim they had portfolio managers making those decisions for them. Whether you believe her or not, Loeffler at least had the good sense to take the issue head-on in a TV interview with Fox's Tucker Carlson (and you can't say he was lobbing her softballs here, either) ...

https://www.youtube.com/watch?v=ube56vaNREc

It's fascinating that so far, those guardians of free speech in the nation's press a/k/a MSM have yet to show any interest in grilling Feinstein or her husband, although the amounts she shifted were the most by far of the 4 senators under scrutiny, and possibly as much alone as those of the other 3 senators combined. In fact, several prominent MSM outlets who've focused their reporting on Burr haven't even mentioned Feinstein's situation. Their seeming overall lack of journalistic curiosity in Feinstein's situation is remarkably similar to their reactions and lack of interest in the Biden family's involvement with Burisma in the Ukraine, and also with the totalitarian Chinese Communist regime.

The overall reporting has gotten so lopsided, it makes President Trump's "enemy of the people" tag retain credible plausibility to folks like me who expect a single-tiered system of justice - not one set of rules if you're an R, and a much more forgiving playing field and set of rules if you're a D. Imagine if a crazed Trump supporter shot Nancy Pelosi in a DC restaurant, just because she was on the "wrong" side? Terrible, right? We agree. But a crazed Bernie supporter shot Steve Scalise on a DC baseball field. No one even ever mentions that anymore. It fell off the news cycle quickly and quietly. Does anyone really think it's the same if it was the other way around? Yeah, right.

It would be shocking (but refreshing) to see someone from the liberal MSM go after someone in the home blues (and mean it) once in awhile. Why doesn't pajama boy whoever Alexander go do some real reporting, and ask DiFi and her husband about her trading activity at around the time Carlson explored with Loeffler (and also rightly castigated Burr)? Go ahead, try it, impress us ...

 

[acs64]

Re: Covid 19

Anyone know if those senators, yes on both sides of the aisle, simply moved out of long positions in the market or they had the nerve to short the market? Either way if they had prior knowledge , especially from some upcoming news related story about the Chinese flu they should be hung from their genitalia.

 

[Wayuphere]

Money still talks, and the NBA is still in bed with the Chinese Communists, as evidenced by the blowback after Morey's comments in September '19. So maybe access to some extra test kits this was a perk to them, in exchange for toeing the line with Beijing?

I know, it sounds crazy … but as you say in the other instance HR, it's not a good look.

I also think the situations with Sen. Burr (R-NC) and Sen. Feinstein (D-CA) on insider trading is appalling. Sen. Loeffler (R-GA) and Sen. Inhofe (R-OK) are also facing questions. Burr and Feinstein seem to have direct day-to-day control over handling of their portfolio (although Feinstein so far seems content with throwing her husband under the bus), while Loeffler and Inhofe claim they had portfolio managers making those decisions for them. Whether you believe her or not, Loeffler at least had the good sense to take the issue head-on in a TV interview with Fox's Tucker Carlson (and you can't say he was lobbing her softballs here, either) ...

https://www.youtube.com/watch?v=ube56vaNREc

It's fascinating that so far, those guardians of free speech in the nation's press a/k/a MSM have yet to show any interest in grilling Feinstein or her husband, although the amounts she shifted were the most by far of the 4 senators under scrutiny, and possibly as much alone as those of the other 3 senators combined. In fact, several prominent MSM outlets who've focused their reporting on Burr haven't even mentioned Feinstein's situation. Their seeming overall lack of journalistic curiosity in Feinstein's situation is remarkably similar to their reactions and lack of interest in the Biden family's involvement with Burisma in the Ukraine, and also with the totalitarian Chinese Communist regime.

The overall reporting has gotten so lopsided, it makes President Trump's "enemy of the people" tag retain credible plausibility to folks like me who expect a single-tiered system of justice - not one set of rules if you're an R, and a much more forgiving playing field and set of rules if you're a D. Imagine if a crazed Trump supporter shot Nancy Pelosi in a DC restaurant, just because she was on the "wrong" side? Terrible, right? We agree. But a crazed Bernie supporter shot Steve Scalise on a DC baseball field. No one even ever mentions that anymore. It fell off the news cycle quickly and quietly. Does anyone really think it's the same if it was the other way around? Yeah, right.

It would be shocking (but refreshing) to see someone from the liberal MSM go after someone in the home blues (and mean it) once in awhile. Why doesn't pajama boy whoever Alexander go do some real reporting, and ask DiFi and her husband about her trading activity at around the time Carlson explored with Loeffler (and also rightly castigated Burr)? Go ahead, try it, impress us ...

You almost made it through a post without going over the edge.

 

[SteveO]

Re: Covid 19

Tough measures enacted by Governor David Y. Ige of Hawaii. Unfortunately unless a vaccine is approved very soon, other states will be forced adopt the same "quarantine doctrine".

Every passenger arriving at a commercial or private airport in the state will be required to fill out a form with information, including where they plan to stay in Hawaii. Arriving passengers must immediately report to their quarantine location upon leaving the airport.

Hawaii residents will self-isolate at home, and visitors will be required to stay in their hotel rooms or “rented lodging” for 14 days or the duration of their stay in the state, whichever is shorter. During the two weeks of isolation, people will only be permitted to leave their quarantine location to seek urgent medical care. Disobeying the order could result in a $5,000 fine and up to a year in prison.

Gov. Cuomo has recently ordered 70,000 Doses of Hydroxylchloroquine, 10,000 doses of Zithromax and 750,000 Doses of Chloroquine to implement RCTs starting Tuesday. NY is the hardest hit state and today documented 5429 new cases bringing the total to 15,801 cases with 114 deaths.

Not sure why Dr. Fauci keeps saying that chloroquine is "anecdotal". I've publish mixed methodology research that included qualitative data analysis which was arguably anecdotal. But two research studies from France and China (in vitro) suggests otherwise and are clearly NOT "anecdotal" evidence. Moreover, that term is most often used when referring to qualitative research, but these are not qualitative designs. Dr. Fauci is rightfully taking a standard of care and experimental design approach to determining the drug's efficacy. But like many of my colleagues in the scientific community there is a tendency dismiss ALL evidential support unless it is subject to robust protocols within RCT research parameters.

In this current environment, I feel Gov. Cuomo in consultation with Dr. Howard A. Zucker, the Commissioner of Health for New York State, is making the correct decision to provide this treatment protocol immediately to those who are struggling with severe viral symptoms and personally request a titration monitored intervention of the treatment dyad. The recommended dosage of Hydroxychloroquine sulfate has a relatively low toxicity profile and researchers suggest front loading 400 mg twice daily for 1 day, followed by 200 mg twice daily for 4 more days.

Having read through the research designs of the drug, one of the most encouraging signs of Hydoxylchloroquine is it's an alkali base that changes the pH on the cellular membrane and that alone has an inhibitory effect. But the true efficacy of it's dyadic intervention coupled with the antibiotic protocol is it's ability to "jam" the mRNA signal sequence and prevent the binding of CoV-19 virion to membrane receptors, and thus viral particles cannot enter the intercellular space of the host to self-replicate. It also has an immunomodulatory effect which may be useful in controlling the "cytokine storm" (severe allostatic overload) that occurs late phase in critically ill SARS CoV 2 (CoV-19) infected who are often elderly patients.

Again not getting my hopes up too high here, but I think we are on to something... Let's see what the RCTs reveal. Quickly, before more precious lives are lost. It's my hope that we can put aside caustic political discourse and come together as a nation united and resilient, carrying each other's burdens until this is clearly defeated.

 

[huskyfan]

Re: Covid 19

Thank you for this post Chuck! This is the second time in four years I’ve heard a Trump voter “admit” that he’s only human and not some kind of holy diety (as he says of himself, “I’ve never made a mistake!” I understand where you’re coming from.

You hang with a rough crowd. I know many many Trump supporters and not one of them think he is a g-d.

 

[e.cat]

Anyone know if those senators, yes on both sides of the aisle, simply moved out of long positions in the market or they had the nerve to short the market? Either way if they had prior knowledge , especially from some upcoming news related story about the Chinese flu they should be hung from their genitalia.

Don't know the answer to that acs but no senator or congressman or congresswoman should be allowed to own individual stocks. Their portfolios should be in blind trusts and managed by independent money managers. It is appalling that this is not the case. DiFi passes the buck and says herhusband is in charge of the blind trust they own. This is the height of arrogance!

 

[huskyfan]

Re: Covid 19

Gov. Cuomo has recently ordered 70,000 Doses of Hydroxylchloroquine, 10,000 doses of Zithromax and 750,000 Doses of Chloroquine to implement RCTs starting Tuesday. NY is the hardest hit state and today documented 5429 new cases bringing the total to 15,801 cases with 114 deaths.

according to the "experts" on the board, he must be an idiot. they all know Chloroquine and Hydroxylchloroquine don't work.

 

[huskyfan]

Re: Covid 19

Don't know the answer to that acs but no senator or congressman or congresswoman should be allowed to own individual stocks. Their portfolios should be in blind trusts and managed by independent money managers. It is appalling that this is not the case. DiFi passes the buck and says herhusband is in charge of the blind trust they own. This is the height of arrogance!

Agree! Always been a Feinstein admirer. This is disappointing.

 

[dxmnkd316]

Re: Covid 19

Edit: not worth it

 

[huskyfan]

Re: Covid 19

Glad you and Gov have created a rush on medicines critical to treating other conditions like infections and lupus on anecdotal data. Great job!

Other conditions are being treated?? I was told things like car accidents and heart attacks would be left to die at the emergency room door. If those aren't emergencies, surely infections aren't!

 

[FadeToBlack&Gold]

Re: Covid 19

Edit: not worth it

None of this thread is worth responding to. Just grab a beverage and snack of your choice and have a sad chuckle at Cult45 in action.

 

[WisconsinWildcard]

Re: Covid 19

Tough measures enacted by Governor David Y. Ige of Hawaii. Unfortunately unless a vaccine is approved very soon, other states will be forced adopt the same "quarantine doctrine".

If you think a vaccine will be approved "soon" you know very little about vaccines. 12-18 months is realistic at best based on current understanding.

Not sure why Dr. Fauci keeps saying that chloroquine is "anecdotal". I've publish mixed methodology research that included qualitative data analysis which was arguably anecdotal. But two research studies from France and China (in vitro) suggests otherwise and are clearly NOT "anecdotal" evidence.

Not sure what your background is but in vitro data is quite suspect for any broad conclusions, especially in clinical medicine. https://xkcd.com/1217/

The recommended dosage of Hydroxychloroquine sulfate has a relatively low toxicity profile and researchers suggest front loading 400 mg twice daily for 1 day, followed by 200 mg twice daily for 4 more days.

You honestly cannot know that. At this point, the evidence that is available is at best hypothesis driving and is no where near what is acceptable for broad clinical application except for a quack. Study it, and then apply it if the data holds.

Having read through the research designs of the drug, one of the most encouraging signs of Hydoxylchloroquine is it's an alkali base that changes the pH on the cellular membrane and that alone has an inhibitory effect. But the true efficacy of it's dyadic intervention coupled with the antibiotic protocol is it's ability to "jam" the mRNA signal sequence and prevent the binding of CoV-19 virion to membrane receptors, and thus viral particles cannot enter the intercellular space of the host to self-replicate. It also has an immunomodulatory effect which may be useful in controlling the "cytokine storm" (severe allostatic overload) that occurs late phase in critically ill SARS CoV 2 (CoV-19) infected who are often elderly patients.

I could say the same thing about hundreds of clinical "cures" that have failed to produce positive results once properly vetted in humans. This sounds like someone who has never ventured out of their lab to talk to a clinician and has ignored the 99% of trials that fail once properly tested. It is incredibly ignorant and reckless to push treatments that we do not know the number needed to treat or number needed to harm into to the public.

The most important lesson to learn as a physician (which is incredibly hard as a compassionate clinician) is to "don't just do something, stand there." Often the best course with incomplete information is to not do anything as we are very susceptible to underestimate harm.

 

[HockeyRef]

Love him or hate him, one has to respect that he has beliefs and stands by them.

Very true.

 

[walrus]

Re: Covid 19

Love him or hate him, one has to respect that he has beliefs and stands by them.

I think if you dig into Rand Pauls positions you will find he is a hypocrite

 

[Chuck Murray]

Re: Covid 19

You almost made it through a post without going over the edge.

Where did it go "over the edge"? Because I asked a simple question about why certain aspects of the media lacks curiosity about certain sensitive persons/topics? After pointing out how an apparently reviled Fox guy had a legitimate go at Sen. Loeffler?

As you can see from other responses (and my post) on the topic, there is no defending Sen. Burr. Who is the superstar on your side of the aisle who dares question DiFi? No one (so far).

Tough measures enacted by Governor David Y. Ige of Hawaii. Unfortunately unless a vaccine is approved very soon, other states will be forced adopt the same "quarantine doctrine".

Gov. Cuomo has recently ordered 70,000 Doses of Hydroxylchloroquine, 10,000 doses of Zithromax and 750,000 Doses of Chloroquine to implement RCTs starting Tuesday. NY is the hardest hit state and today documented 5429 new cases bringing the total to 15,801 cases with 114 deaths.

Not sure why Dr. Fauci keeps saying that chloroquine is "anecdotal". I've publish mixed methodology research that included qualitative data analysis which was arguably anecdotal. But two research studies from France and China (in vitro) suggests otherwise and are clearly NOT "anecdotal" evidence. Moreover, that term is most often used when referring to qualitative research, but these are not qualitative designs. Dr. Fauci is rightfully taking a standard of care and experimental design approach to determining the drug's efficacy. But like many of my colleagues in the scientific community there is a tendency dismiss ALL evidential support unless it is subject to robust protocols within RCT research parameters.

In this current environment, I feel Gov. Cuomo in consultation with Dr. Howard A. Zucker, the Commissioner of Health for New York State, is making the correct decision to provide this treatment protocol immediately to those who are struggling with severe viral symptoms and personally request a titration monitored intervention of the treatment dyad. The recommended dosage of Hydroxychloroquine sulfate has a relatively low toxicity profile and researchers suggest front loading 400 mg twice daily for 1 day, followed by 200 mg twice daily for 4 more days.

Having read through the research designs of the drug, one of the most encouraging signs of Hydoxylchloroquine is it's an alkali base that changes the pH on the cellular membrane and that alone has an inhibitory effect. But the true efficacy of it's dyadic intervention coupled with the antibiotic protocol is it's ability to "jam" the mRNA signal sequence and prevent the binding of CoV-19 virion to membrane receptors, and thus viral particles cannot enter the intercellular space of the host to self-replicate. It also has an immunomodulatory effect which may be useful in controlling the "cytokine storm" (severe allostatic overload) that occurs late phase in critically ill SARS CoV 2 (CoV-19) infected who are often elderly patients.

Again not getting my hopes up too high here, but I think we are on to something... Let's see what the RCTs reveal. Quickly, before more precious lives are lost. It's my hope that we can put aside caustic political discourse and come together as a nation united and resilient, carrying each other's burdens until this is clearly defeated.

Fantastic post. And to those tut-tutting about this, please remember … BOTH Governor Cuomo and President Trump have agreed to try out this approach to treatment. Some folks are optimistic; no one is guaranteeing anything. It's low toxicity. Why not try?

Waiting for quiz answer Darius to check in with his review on today's press conference. Personally, I thought it went well, but other opinions are always enlightening ...

 

[Slap Shot]

Re: Covid 19

Jeezuz you pick and choose what you like and ignore the rest.

 

[Wayuphere]

Where did it go "over the edge"? Because I asked a simple question about why certain aspects of the media lacks curiosity about certain sensitive persons/topics? After pointing out how an apparently reviled Fox guy had a legitimate go at Sen. Loeffler?

As you can see from other responses (and my post) on the topic, there is no defending Sen. Burr. Who is the superstar on your side of the aisle who dares question DiFi? No one (so far).



Fantastic post. And to those tut-tutting about this, please remember … BOTH Governor Cuomo and President Trump have agreed to try out this approach to treatment. Some folks are optimistic; no one is guaranteeing anything. It's low toxicity. Why not try?

Waiting for quiz answer Darius to check in with his review on today's press conference. Personally, I thought it went well, but other opinions are always enlightening ...

I’m on neither side of the aisle. I sit in the aisle, always have. As far as insider trading, anyone from any party who profits from this should be hung from a post. I’ve always said, hang a rope from the Washington monument for ANY politician who abuses their position to the extreme.(relax folks, a metaphor.)
As far as which news services report negative stories based on party, that will never change, left or right. The days of evening real news followed by a 5 minute editorial, where we were told it was an opinion only, are long passed by.
That is sad. It leads to what we have now.

 

[WisconsinWildcard]

Re: Covid 19

And to those tut-tutting about this, please remember … BOTH Governor Cuomo and President Trump have agreed to try out this approach to treatment. Some folks are optimistic; no one is guaranteeing anything. It's low toxicity. Why not try?

Noted physician scientists Dr. Cuomo and Dr. Trump....I am really reassured by their evidence-free recommendations. We need to wait for controlled trials (which by the way are not difficult to run in this setting) before making broad based conclusions. This is experimental and should be limited to experiments.

And low toxicity? Its most well known side effect is blindness...*




I actually use this medication off-label for accepted uses and perform regular retinal screening on these patients. I do know several patients (none of my own as of yet) who have experienced severe retinal complications.