Just booked NYC for August 11-14. By the time I come in from LaGuardia, I arrive at my Times Square hotel around 3 PM Thursday, and I am there until around 5 PM Sunday (when I need to head back to LGA). I have never been to Manhattan (passed close a couple times). I have a semi-rough list of what I think I want to try and do for what amounts to about a 3.5 day first trip:
- Statue/Ellis Island
- Empire State
- Ground Zero
- One of the museums (which one has the broadest appeal?)
- Colbert taping (I know I'll need to book in advance for the 6:30 taping on 8/11, and be there pretty early - does anyone have an idea of how early?)
- Broadway (currently aiming to do at least one, maybe two shows, and I am aware of both the eye-popping prices for first-run shows, and the same-day discount options for shows that have been running for a long time - I've been evaluating my options. I already know I'm not getting into Hamilton without connections.
)
- Nightlife (Smalls Jazz Club?, etc)
- Food (Deli, Pizza, Chinese, Le Bernardin?, one of the big steakhouses?, one of Boulud's restaurants?, Bouley?, Marea?, etc) - I am obviously planning a really big budget for this part of the trip

Any suggestions or dissuasions are welcome.
Oh Man, where to begin... in a city like New York, you're going to get what you want, and what you want is entirely up to
YOU. Take everyone else's suggestions with a grain of salt. So on that note... here's my salt. :0)
Museums: Natural History cannot be beat, but much like any museum, spend some time there... don't just walk-through for the "been there, got a tee-shirt" objective. And while you're there, Hayden Planetarium is also a great exhibit. If you are a fellow techie/nerd, or a military history buff, try the Intrepid Sea, Air, & Space Museum. Haven't been back since they dropped the Space Shuttle there, but I'll get there soon. (LOVE the SR-71 there!, plus my father served on that ship, so I'm a bit partial)
Food: Curry Row... Sixth St between 1st & 2nd Ave. On the 'hit list' of
every NYC trip for me, but be warned... Curry can be a powerful laxative!! I have a very bad/"entertaining" (entertaining for
some, but not
me!!) Grand Central Station story about that!! Despite that very,
very bad experience, I absolutely LOVE Curry Row. But really, there are SO many great places to eat in Manhattan (Hell's Kitchen is LOADED with good places), you're going to find a good place by accident... and that will lead to the absolute BEST experience by-far!. 'Yelp' is your friend... use 'her'!!!
Nightlife: Unfortunately, we are at a point in life where we cannot enjoy the nightlife due to children who cannot be left-alone (yet!). One of my 'bucket list' objectives is to get to a comedy club in midtown, so if you happen to 'live my dream'... I'm all ears!!! Seeing that you are in the Times Square area, you will have plenty of options. Again, 'Yelp' is your friend. As for Bars/Pubs, my only nightlife advise is the same I applied to myself in New Orleans, and pretty-much
everywhere I go... get out of the 'touristy areas', and drink with the locals... you will not regret it (provided you are 'cool' and can 'hang' with the locals). But I will admit... getting-away from the tourists is going to be difficult in the Theater District! Talk to your Concierge, and tip the man! :0) (Absolute
best resource for info at the hotel!!)
Getting-around: I am certainly a 'budget' Subway Man. If you choose to be the same, get an App, and a Metro card. Taxi's are great, but I just prefer the 'underground'. To be honest, even walking is good enough for me... walked with the family from the Financial District (Millinium Hilton) to Penn Station one trip, and saw a
ton... Little Italy, NYU, Washington Square, Flatiron District... great walk, except Korea Town got a wee-bit 'hairy'!!
Touristy-poo: Morning shows ('Today' in Rockefeller Center), Rockefeller Center in-general, shopping in-general (Sony store, Apple Store, Toys-R-Us). Central Park (although walking-around can be 'fun'), Bronx Zoo (haven't been there in years!). As for Times Square, just like every other overly-touristy area (Quincy Market, National Mall, Inner Harbor, North Beach, Bourbon St, Miracle Mile, Gaslight District, Hollywood Blvd, etc, etc, etc), walk-in, observe, walk-through, observe, walk-out, observe, and
leave... no need to return (but of course, snap a photo while you're there!).
You will fill your days on Manhattan, but know that there are so many more places in the Boroughs to explore. Save them for another day, and enjoy this trip! Make some memories, and come-back for more!
Cheers!!! (and safe travels)
~TTF