Makes me wonder about leaky gut. I have a friend who works in GI- who does a lot with that.
Very simplified- your gut is populated with a bacteria. Different parts of the bowel should have different populations- she described it sort of like each 'address' has a different population. This is a coordinated system that allows things to be digested properly so the different nutrients/components pass into the circulation in small enough particles.
If the system is disrupted then then the particles that pass thru into the circulation are not broken down properly and are larger. Larger particles cause the body to be constantly in a low grade immune response at baseline. This causes hyper reaction to things that are introduced to the system- increased allergic responses, amplified symptoms that previously were not noticeable or mild. They actually have ways to test for this and ways to correct it but it is wickedly complex regimen and means a lot of dietary changes, supplements , other stuff. I had patients she treated who were train wrecks- multiple problems, meds, etc who ended up coming off almost everything.
Increased incidence in people who take PPIs, have used steroids or antibiotics (which depopulate the good bacteria).
It is totally fascinating.
It's insanely interesting.
My gf developed a severe gluten intolerance about 4-5 years ago. She was sick all the time. Tried cutting out this and that, no help. Her singer in her band has Celiak and suggested she just try cutting gluten. So my girlfriend did and within 2 days she felt 100% better. This was great news (except for the fact that cutting gluten is difficult for an italian from NY), and she lived like this for a few years. It was wild - she'd get sick, track her food and find nothing with gluten in it, only to find that the new bottle of ibuprofen we just got contained gluten (or other crazy minutiae).
Fast forward to 2019 and she develops a nasty case of diverticulitis. Then another one several months later. Two rounds of strong antibiotics later and the DV is gone... and suddenly she can eat gluten again.
Our bodies are weird.