I really don't think #1 overall will mean that much this year. It is highly likely that the #16 seed will be from out east (likely Atlantic Hockey auto bid, but possibly ECAC auto bid), and will be kept out east. Further, North Dakota is locked into the Fargo regional, and BC is going to stay in an eastern regional, so it's not likely they will need any protection from a travel standpoint. Minnesota and Mankato are flying regardless.
I suppose the one scenario where it could matter is if Minnesota or Mankato get the #1 overall seed, and get sent to an eastern regional to take on the #16 seed, instead of that team playing BC.