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Covfefe-19 The 12th Part: The Only Thing Worse Than This New Board Is TrumpVirus2020

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rufus said:
Based on stories we've been hearing about mutations, I would guess yes.
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Maybe. This isn’t a traditional vaccine. At least not the mRNA one. I’m not sure we know how long it will last until we get to phase 4.

edit: I thought I remember reading the mRNA vaccine should be fairly effective even against all but the most drastic mutations. I thought it targeted the spike or one of the receptors (perhaps those are the same?) which would be fairly ubiquitous across all SARS-CoV-2 virus strains.

There was also also an article in the NYT saying immunity from recovered cases seems to be showing signs of longer term effect than previously thought. Obviously not The Lancet, but I’d guess they cited at least one peer-reviewed paper.
 
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Interesting. So the astra Zeneca vaccine isn’t an mRNA vaccine. It’s seemingly less effective in the overall numbers (70%) but that comes with a couple asterisks.

First, they tested everyone in their studies, not just symptomatic individuals. Could be hurting their numbers.

Second, there was a small sub study that showed 90% effectiveness when given a low dose first, then a high dose booster later. One of the accounts I posted above seemed to think it was basically the body’s immune system reacting strongly to the high dose blocking the effectiveness of the booster https://twitter.com/profshanecrotty/...782379009?s=21

Third, it seems to promote a longer lasting immunity. Some people are pointing to it as longer than just a few months but potentially years.

Here’s where it gets interesting. mRNA vaccines are short lived in the body. Months (maybe more, maybe less). But that actually could be fairly useful. If the mRNA vaccine isn’t as effective against a mutation later, it won’t last long enough to block a second vaccine later. That’s what they might be seeing in that High-High 70% vs Low-High 90%. So it’s more like a chalkboard than parchment. The body erases its immune response so it doesn’t block future vaccines.

That got me thinking. Could this could lead to a new approach to pandemics? Design the precision strike mRNA vaccine quickly in parallel to the vector vaccine, mass produce both to get as many people as possible. Blanket the population with as many doses as possible and come clean up the short term fixes later with a vector vaccine once we’ve had enough time to mass produce enough doses.

Infectious disease medicine has and will advance faster over this pandemic than the previous decade. Brought mRNA vaccines to the limelight and opened doors for all sorts of future research into them. Which is also where the punchline comes in. Turns out the lady who helped develop the concept of mRNA vaccines had her mRNA grants pulled years and years ago and she got demoted at Penn. She left and went to Moderna and possibly helped save the world. And probably win the Nobel in medicine and a very sizable paycheck. Sometimes the universe makes things right.
 
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The fact is, we don't know how long the COVID-specific memory antibodies last in "normal" human bodies. All the scary articles about "antibody levels dropping after recovery" leave off the important fact that all AB levels drop after beating any infection - this is totally normal. What matters are how long those last, and we do not yet know.

I think the 6 week cyclical fear mongering over re-infections is mostly garbage - in a world with tens of millions of infections, it isn't surprising to have many reinfections. That does not, however, mean the majority of people will not get at least some level of immunity.


One thing to keep in mind - this virus, structurally, is nothing like influenza. Influenza mutates nonstop. It's extremely unstable, and that's why we need yearly shots to cover those newly mutated strains. Historically, coronaviruses are far more stable. Sure, they mutate (all viruses do), but at a much slower rate than influenza. The fact that we're noticing many minor mutations is just a result of the tens of millions of concurrent infections: the virus is nearly endemic and therefore has many chances to mutate. Once we get it under control via inoculation, those chances will be much fewer and we'll see many fewer noticeable mutations. Hopefully.


But the fact is, we don't know. It's still a novel virus.
 
I finally tested negative, with that happy test result coming early last week. But for a few weeks now I have had the oddest of what I was wonder is some lingering COVID symptom. I smell cigarette smoke. Constantly. It is bizarre. Sometimes it is overwhelming.

No one is in my house other than me, and I wouldn't let anyone smoke here anyway. I am never around smokers here in WI since with COVID I have worked only from my home and obviously no one is smoking in the few places I ever go. No one in my family even smokes cigarettes, and the only kinds of smokers (one pot, one those little cigars) live in Indiana.

Right now, it smells like there are 3 smokers in my home office (a spare bedroom) and the door and windows are closed. I hate the smell of cigarette smoke. I would stop short of calling it nauseating, but just short. What's worse is now when I sense the slightest hint of it, I begin to fixate on it. I honestly can't remember the last time I was in a room with a smoker since you can't smoke inside virtually any establishment, and I don't hang with smokers in their homes and don't really have any contact with smokers up close to even smell it in their clothes. Yet my nose feels like it is made of the inside of an ashtray.
 
A quick google shows you’re not alone in the cigarette smoke issue
 
WeAreNDHockey said:
I finally tested negative, with that happy test result coming early last week. But for a few weeks now I have had the oddest of what I was wonder is some lingering COVID symptom. I smell cigarette smoke. Constantly. It is bizarre. Sometimes it is overwhelming.

No one is in my house other than me, and I wouldn't let anyone smoke here anyway. I am never around smokers here in WI since with COVID I have worked only from my home and obviously no one is smoking in the few places I ever go. No one in my family even smokes cigarettes, and the only kinds of smokers (one pot, one those little cigars) live in Indiana.

Right now, it smells like there are 3 smokers in my home office (a spare bedroom) and the door and windows are closed. I hate the smell of cigarette smoke. I would stop short of calling it nauseating, but just short. What's worse is now when I sense the slightest hint of it, I begin to fixate on it. I honestly can't remember the last time I was in a room with a smoker since you can't smoke inside virtually any establishment, and I don't hang with smokers in their homes and don't really have any contact with smokers up close to even smell it in their clothes. Yet my nose feels like it is made of the inside of an ashtray.
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The singer for an Alice In Chains tribute band I play with is sick and noted similar symptoms. Not cigarette smoke, but that everything smells awful. He said certain things smell like battery acid.

Glad you're doing better, other than that bizarre thing.
 
Deutsche Gopher Fan said:
A quick google shows you’re not alone in the cigarette smoke issue
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Well at least I know I am not imagining this. Well, I guess I am imagining this, but at least COVID might actually be the reason my brain is having a little fun with me. I want to say this is just another way I consider myself lucky as there are certainly more debilitating symptoms of COVID. But there's a reason I have never smoked a single, solitary cigarette in my entire life. Cigarettes smell GROSS.
 
Swansong said:
It's really enlightening to see just how self centered so many people are, and how so many of them claim to be Christians.

How very charitable.
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And then see them a few weeks letter asking for thoughts and prayers. I think anyone who posts this crap publicly should be denied medical help. If they choose to ignore doctors doctors should ignore them. Triage means you have to choose who needs the help more and these clowns are showing they dont.

Sorry but I am done with this BS "Freedumb" crap. If you don't want to live by the rules of a society you get none of the benefits of said society.
 
WeAreNDHockey said:
I finally tested negative, with that happy test result coming early last week. But for a few weeks now I have had the oddest of what I was wonder is some lingering COVID symptom. I smell cigarette smoke. Constantly. It is bizarre. Sometimes it is overwhelming.

No one is in my house other than me, and I wouldn't let anyone smoke here anyway. I am never around smokers here in WI since with COVID I have worked only from my home and obviously no one is smoking in the few places I ever go. No one in my family even smokes cigarettes, and the only kinds of smokers (one pot, one those little cigars) live in Indiana.

Right now, it smells like there are 3 smokers in my home office (a spare bedroom) and the door and windows are closed. I hate the smell of cigarette smoke. I would stop short of calling it nauseating, but just short. What's worse is now when I sense the slightest hint of it, I begin to fixate on it. I honestly can't remember the last time I was in a room with a smoker since you can't smoke inside virtually any establishment, and I don't hang with smokers in their homes and don't really have any contact with smokers up close to even smell it in their clothes. Yet my nose feels like it is made of the inside of an ashtray.
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Definitely not alone alone....I smelt weird crap for a couple weeks after my 1st positive...It was so bad it made me throw up
 
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