Re: Covid 19
Tough measures enacted by Governor David Y. Ige of Hawaii. Unfortunately unless a vaccine is approved very soon, other states will be forced adopt the same "quarantine doctrine".
Gov. Cuomo has recently ordered 70,000 Doses of Hydroxylchloroquine, 10,000 doses of Zithromax and 750,000 Doses of Chloroquine to implement RCTs starting Tuesday. NY is the hardest hit state and today documented 5429 new cases bringing the total to 15,801 cases with 114 deaths.
Not sure why Dr. Fauci keeps saying that chloroquine is "anecdotal". I've publish mixed methodology research that included qualitative data analysis which was arguably anecdotal. But two research studies from France and China (in vitro) suggests otherwise and are clearly NOT "anecdotal" evidence. Moreover, that term is most often used when referring to qualitative research, but these are not qualitative designs. Dr. Fauci is rightfully taking a standard of care and experimental design approach to determining the drug's efficacy. But like many of my colleagues in the scientific community there is a tendency dismiss ALL evidential support unless it is subject to robust protocols within RCT research parameters.
In this current environment, I feel Gov. Cuomo in consultation with Dr. Howard A. Zucker, the Commissioner of Health for New York State, is making the correct decision to provide this treatment protocol immediately to those who are struggling with severe viral symptoms and personally request a titration monitored intervention of the treatment dyad. The recommended dosage of Hydroxychloroquine sulfate has a relatively low toxicity profile and researchers suggest front loading 400 mg twice daily for 1 day, followed by 200 mg twice daily for 4 more days.
Having read through the research designs of the drug, one of the most encouraging signs of Hydoxylchloroquine is it's an alkali base that changes the pH on the cellular membrane and that alone has an inhibitory effect. But the true efficacy of it's dyadic intervention coupled with the antibiotic protocol is it's ability to "jam" the mRNA signal sequence and prevent the binding of CoV-19 virion to membrane receptors, and thus viral particles cannot enter the intercellular space of the host to self-replicate. It also has an immunomodulatory effect which may be useful in controlling the "cytokine storm" (severe allostatic overload) that occurs late phase in critically ill SARS CoV 2 (CoV-19) infected who are often elderly patients.
Again not getting my hopes up too high here, but I think we are on to something... Let's see what the RCTs reveal. Quickly, before more precious lives are lost. It's my hope that we can put aside caustic political discourse and come together as a nation united and resilient, carrying each other's burdens until this is clearly defeated.
Tough measures enacted by Governor David Y. Ige of Hawaii. Unfortunately unless a vaccine is approved very soon, other states will be forced adopt the same "quarantine doctrine".
Every passenger arriving at a commercial or private airport in the state will be required to fill out a form with information, including where they plan to stay in Hawaii. Arriving passengers must immediately report to their quarantine location upon leaving the airport.
Hawaii residents will self-isolate at home, and visitors will be required to stay in their hotel rooms or “rented lodging” for 14 days or the duration of their stay in the state, whichever is shorter. During the two weeks of isolation, people will only be permitted to leave their quarantine location to seek urgent medical care. Disobeying the order could result in a $5,000 fine and up to a year in prison.
Hawaii residents will self-isolate at home, and visitors will be required to stay in their hotel rooms or “rented lodging” for 14 days or the duration of their stay in the state, whichever is shorter. During the two weeks of isolation, people will only be permitted to leave their quarantine location to seek urgent medical care. Disobeying the order could result in a $5,000 fine and up to a year in prison.
Not sure why Dr. Fauci keeps saying that chloroquine is "anecdotal". I've publish mixed methodology research that included qualitative data analysis which was arguably anecdotal. But two research studies from France and China (in vitro) suggests otherwise and are clearly NOT "anecdotal" evidence. Moreover, that term is most often used when referring to qualitative research, but these are not qualitative designs. Dr. Fauci is rightfully taking a standard of care and experimental design approach to determining the drug's efficacy. But like many of my colleagues in the scientific community there is a tendency dismiss ALL evidential support unless it is subject to robust protocols within RCT research parameters.
In this current environment, I feel Gov. Cuomo in consultation with Dr. Howard A. Zucker, the Commissioner of Health for New York State, is making the correct decision to provide this treatment protocol immediately to those who are struggling with severe viral symptoms and personally request a titration monitored intervention of the treatment dyad. The recommended dosage of Hydroxychloroquine sulfate has a relatively low toxicity profile and researchers suggest front loading 400 mg twice daily for 1 day, followed by 200 mg twice daily for 4 more days.
Having read through the research designs of the drug, one of the most encouraging signs of Hydoxylchloroquine is it's an alkali base that changes the pH on the cellular membrane and that alone has an inhibitory effect. But the true efficacy of it's dyadic intervention coupled with the antibiotic protocol is it's ability to "jam" the mRNA signal sequence and prevent the binding of CoV-19 virion to membrane receptors, and thus viral particles cannot enter the intercellular space of the host to self-replicate. It also has an immunomodulatory effect which may be useful in controlling the "cytokine storm" (severe allostatic overload) that occurs late phase in critically ill SARS CoV 2 (CoV-19) infected who are often elderly patients.
Again not getting my hopes up too high here, but I think we are on to something... Let's see what the RCTs reveal. Quickly, before more precious lives are lost. It's my hope that we can put aside caustic political discourse and come together as a nation united and resilient, carrying each other's burdens until this is clearly defeated.
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